Onyx Scientific offers specialist Solid State Chemistry that is integrated with our other chemistry service and focused on cutting lead times and ensuring processes are scaleable. Such chemistry can be carried out in parallel with process development or after depending on your project’s needs.
Given that a high percentage of all drugs are formulated in solid dosage form, the need to understand, control and characterise the individual forms of a drug substance, particular the polymorphic form, is vital. Each polymorph displays unique physicochemical properties that can affect bioavailability, manufacturability, stability and other performance characteristics of the drug.
Appropriate polymorphic form selection with desirable properties (e.g. for filtration) can be of huge benefit to process efficiency and/or purity and play an important part in Intellectual Property (IP) strategy throughout a drug’s life-cycle.
The following links provide additional information to the various aspects of our Solid State chemistry and polymorphism services:
- Physicochemical Property Determination
- Polymorph Screening
- Salt Screening and Selection
- Crystallisation Process Development & Optimisation
- Rapid Chiral Resolution Screening
- Integrated Manufacturing & Solid State Services